Getting to know Antiarrhythmic Medication Group II

Medications that prevent or treat cardiac arrhythmias are called antiarrhythmics. Antiarrhythmic drugs are classified according to their use in 5 groups.

Group II is beta-adrenergic which inhibits the agent preventing stimulation of beta-adrenergic receptors of nerve endings in the sympathetic nervous system and decreases cardiac activity. These drugs reduce systolic pressure, heart rate, heart contractions and output, decrease myocardial oxygen demand and increase exercise tolerance.

Beta adrenergic-inhibiting agents are used in the treatment of angina, controlling heart rate abnormalities, and reducing high blood pressure. However, inhibition of beta receptors can cause bronchial constriction, so the use of beta blockers must be done carefully in patients with respiratory conditions.

Cardioselective beta-blockers (beta1-selective blockers) have advantages in which they affect the heart, which has beta1 receptors. The effects of broncho-constriction can be reduced by beta1 selective blockers, where the bronchial muscles have an excess of beta2 receptors. But the danger of broncho-constriction cannot be allowed, because they are not entirely selective.

Beta blockers can include:

  • Acebutolol - Sectral
  • Atenolol - Tenormin
  • Betaxolol - Betoptic, Betoptic S, Kerlone
  • Bisoprolol - Zebeta
  • Carteolol - Oral Cartrol, Ocupress Ophthalmic
  • Celiprolol - Celol
  • Esmolol - Brevibloc
  • Labetalol - Normodyne, Trandate
  • Levobetaxolol - Betaxon
  • Levobunolol - Betagan
  • Metipranolol - Optipranolol
  • Metoprolol - Lopressor, Toprol XL
  • Nadolol - Corgard
  • Penbutolol - Levatol
  • Pindolol - Visken
  • Propranolol - Inderal, Inderal LA
  • Sotalol - Betapace AF, Betapace
  • Timolol - Betimol, Blocadren, Timoptic-XE, Timoptic, Timoptic OcuDose

The role of antiarrhythmic drugs in the management of heart disease

Beta-adrenergic blockers are one of the most commonly given cardiovascular drugs. Many beta-blockers are available for clinical use. Although these agents are different, there is no clear difference in relevance, other than beta1-, beta2- and alpha-adrenergic receptors. The choice of agent and target dose is best with experimental data instructions, although limited.

Nonselective agents (with or without alpha-blocking traits) without Intrinsic Sympathetic Activity (ISA) are the most appropriate postinfarction. Evidence shows postinfarction mortality benefits for propranolol, timolol, metoprolol, and in left ventricular dysfunction, carvedilol.

In conditions of heart failure, selective agents metoprolol, bisoprolol, and nonselective agents carvedilol have the advantage of mortality. Not all tolerated beta-blockers are associated with survival benefits and may not be recommended for extrapolating benefits in similar drugs. Carvedilol can have advantages over other beta-blockers and possible survival benefits, although this discovery is not universally accepted.

The choice of a specific agent prevents clear contraindications and uses experimental data to help with selection and dosage as long as there are no side effects or can be tolerated.

Left ventricular hypertrophy is a strong predictor of cardiovascular mortality and morbidity and regression reduces risk, free from the effects of blood pressure reduction. In patients with hypertension, drugs that suppress LVH are needed. In the Life study, antihypertensive treatment with losartan-based therapy resulted in greater LVH suppression compared to conventional atenolol-based therapy. In a meta-analysis of 104 studies comparing antihypertensive strategies in LVH regression, beta-blocker-based therapy produced at least LVH regression compared with RAAS blockers, malignant calcium, and diuretics. Beta-blockers do not reduce collagen content in the myocardium and are not effective in LVH regression. Therefore, the benefits of beta-blockers in patients with LVH are questionable.

Always consult a doctor before using group II antiarrhythmics. Inform your doctor if you are or are planning to become pregnant or are breastfeeding. Also tell the doctor what treatment you are using, including natural and herbal supplements.

Tell your doctor if you have allergies to group II antiarrhythmic treatment.

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